Estrovera features ERr 731, a plant-based and hormone-free ingredient clinically proven to relieve 12 of the most common symptoms of menopause by up to 83%. View abstract. Both brands claim that their products provide numerous benefits: Amberen claims that their Multi-Symptom Menopause Relief product relieves 12 symptoms, including: The supplements come as capsules and help restore hormone balance. Yokozawa, T., Fujioka, K., Oura, H., Nonaka, G., and Nishioka, I. 18 Patients with atherosclerosis were given rhubarb extract 50 mg/kg for 6 months. All trademarks, registered trademarks and service-marks mentioned on this site are the property of their respective owners. Prolonged episodes of diarrhea may increase your risk of becoming dehydrated. View abstract. However, one of the products main ingredients is black cohosh. Goel, V., Cheema, S. K., Agellon, L. B., Ooraikul, B., and Basu, T. K. Dietary rhubarb (Rheum rhaponticum) stalk fibre stimulates cholesterol 7 alpha-hydroxylase gene expression and bile acid excretion in cholesterol-fed C57BL/6J mice. 4) Treats cold sores. 2010 Feb 19;5:7. doi: 10.1186/1749-8546-5-7. J Ethnopharmacol. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Zhou, L., Hao, R., and Jiang, L. [Clinical study on retarding aging effect of tongbu recipe to traditional Chinese medicine]. Br J Pharmacol 2001;134(1):11-20. Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others. Potential preventive and therapeutic effect of Chinese herb rhubarb (da huang) for intensive care unit/pediatric intensive care unit gastrointestinal failure patients: A protocol for systematic review. 1996;11(1):186-190. (Chinese Journal of Modern Developments in Traditional Medicine) 1986;6(11):665-6, 644. SSO.Schweiz.Monatsschr.Zahnheilkd. Some of these medications that can harm the kidneys include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others. Shanxi Journal of Nursing 1997;11(6):262-263. Rhaponticum carthamoides (Russian Leuzea or Maral Root) is an herb used in traditional Siberian and Russian medicine to bolster physical performance particularly after illness, in addition to being used as a general physical enhancement and male sexual enhancement aid. We follow a strict editorial policy, especially related to the sources we use. Wang, H. H. Antitrichomonal action of emodin in mice. Another study showed that emodin inhibits human cancer cell invasiveness by specifically antagonizing the adenosine 5-triphosphate-gated Ca(2+)-permeable channel P2X7 receptor(17). Taking rhubarb along with some medications for inflammation might decrease potassium in the body too much. In a small study of lung cancer patients, a rhubarb extract reduced radiation-induced lung toxicity and increased pulmonary function . [Chinese Journal of Integrated Traditional and Western Medicine] 1986;6(8):458-459, 451. There are no warnings to suggest that these supplements would interact. In each of these, a pill containing the extract (ERr) significantly reduced vasomotor and other menopausal symptoms. 1994;14(4):230-1, 198. Beck S, Richardson A, et al. The most common drug interactions associated with rhubarb involve antibiotics like penicillin, erythromycin, and amoxicillin. Your email address will not be published. Jiao, D. H. [Alcoholic extract tablet of rhubarb in treating acute upper gastrointestinal hemorrhage]. Rhubarb stem, when taken in the form of food, is considered to be safe. Chin Med. Fan, J. G. Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial. 1991;11(7):418-9, 390. Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones. Yang, N., Liu, X., and Lin, Q. View abstract. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Some medications that can harm the liver include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo). The products website claims that Estrovera is the new gold standard for menopause relief. Acute renal failure has been associated with long-term anthraquinone use. Other ingredients: enteric coating, ammonium hydroxide, oleic acid, croscarmellose sodium, and others of the kind. Research and studies on both products are limited: A 2019 study split people experiencing menopause symptoms into two groups. The anti-inflammatory activity of emodin may mediate rhubarbs hepatoprotective effects in rats with cholestatic hepatitis(11). Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). Chen, X. and Ran, R. [Rhubarb decoction prevents intestinal bacterial translocation during necrotic pancreatitis]. At the same time, the British East India Company secured their positions in Chinese ports. Zhou, H. and Jiao, D. [312 cases of gastric and duodenal ulcer bleeding treated with 3 kinds of alcoholic extract rhubarb tablets]. These products include Stress Relief & Energy Boost, Weight Management, and Sleep Cool. Taking rhubarb along with medication that might also harm the liver can increase the risk of liver damage. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Additional studies suggest that aloe-emodin exerts anti-proliferative activity, inducing cell cycle arrest in cancer cell lines(6). However, both brands have received negative customer reviews that mention side effects. View abstract. Dr Oz: Siberian Rhubarb Extract Supplements Remedy: - Siberian Rhubarb Extract Supplements: Take 4 mg once a day. A total of 12 studies enrolling 968 participants were identified; ages of participants ranged from 57 to 69 years, all were Chinese, disease duration ranged from 6 hours to 14 days, and study duration ranged from 1 week to 30 days. Calcium oxalate crystals form and occlude the dentinal tubules responsible for sensitization.42, A Cochrane systematic review and meta-analysis of dietary supplements for dysmenorrhea identified only low or very low quality studies with very small sample sizes. See additional information. 2. Last medically reviewed on December 23, 2021. Rhubarb is high in oxalates, and maycause kidney problems in some individuals. 1 On this basis, extracts of rhubarb have been tried for control of menopausal symptoms.In a 12-week, double-blind, placebo-controlled trial of 109 women with menopause-related problems, use of a standardized Rheum rhaponticum. Greenway FL, Liu Z, Martin CK, et al. The constituents of R. officinale are similar to those of Chinese Rhubarb. Further a recent preclinical study excluded unwanted side effects on Significant overall clinical efficacy was demonstrated in the rhubarb intervention group compared with Western medicine controls (n = 788; relative risk [RR] = 1.27; P < 0.01); all trials had a relatively high risk of bias and the funnel plot indicated publication bias. Yarnell E. Rhubarb and diabetic nephropathy. Anthraquinone extracts of rhubarb induced cytotoxicity in cancer cell lines(5) and tumor necrosis in mice(1), although this has not been demonstrated in humans. Chinese Journal of Nursing 1995;7(30):420-422. Disclosure of Material connection: Some of the links in the post above are "associate sales links." Rhubarb is LIKELY SAFE when the root is consumed as food. Estrovera does seem like a reliable menopause relief product that women could take advantage of to handle their symptoms of menopause. Abdominal pain and cramping. View abstract. Please follow the instructions listed below to upload your electronic proof of purchase. It is a strong cathartic and is thought to increase the excretion of waste products, including nitrogenous waste accumulated in patients with renal failure, through the intestines. 1980;90(8):718-724. 2000;20(2):107-109. [Top of Rhubarb, English] ---Constituents---Root. From diagnosis to treatment, our experts provide the care and support you need, when you need it. 2006;30:1737-41. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Rhubarb is a type of laxative called a stimulant laxative. This information is not specific medical advice and does not replace information you receive from your health care provider. It claims that this produces no adverse side effects. 3 E Evergreen Road #1193, New City, NY 10956 A: The product is not to be used by women who are currently pregnant or nursing. It may also reduce excess blood levels of pancreatic enzymes and pancreatitis events caused by some procedures. 1991;53(4):181-183. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Rhapontic Rhubarb Root extract, Microcrystalline Cellulose, Stearic Acid, Silica, and Sodium. View abstract. Der Freie Zahnarzt 1997;9:76-80. * However, the molecular basis of its clinical effectiveness remains obscure. This is only a brief summary of general information about this product. "Water pills" can also decrease potassium in the body. If you already have kidney disease, don't risk making it worse by taking rhubarb. A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. RxList does not provide medical advice, diagnosis or treatment. The first reported sighting of the plant in situ was in the mountains of Bulgaria. The product could help you ease the symptoms of menopause, It might be able to reduce pain, anxiety, restlessness, and other commonly associated symptoms, It could help you get through the episodes of hot flashes, The ingredients are entirely natural and there are no chemicals, The product is brought to you by a reliable manufacturer, Data from scientific testing is not shown. But in the wake of studies that suggest HRT may increase the risk of heart diseaseheart disease and breast cancer, they are currently recommended only for short-term use. WHAT IS RHUBARB ROOT? It is created by eHealthMe based on reports of 163 people who have side effects while taking Rhubarb from the FDA, and is updated regularly. Lindeyin, a phenolic gallylglucoside, exhibits analgesic and anti-inflammatory properties in animal models. View abstract. Bi ZQ, Kang ZQ, and Zheng FL. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials.". No medical claims are implied in this content, and the information herein is not intended be used for self-diagnosis or self-treatment of any condition. However, a person should speak with a doctor before taking either product. For treatment of cold sores: a cream containing 23 mg/gram each of rhubarb extract and sage extract applied every 2 to 4 hours while awake, with treatment starting within one day of symptom appearance and continuing for 10 to 14 days. Sept. 15, 2006 -- A pill made from rhubarb may help treat the symptoms of perimenopause, including hot flashes, according to a new study. Pursuing basic and translational research across 9 programs and 100+ labs, Focusing on clinical cancer research and population health, Bridging the lab and the clinic through translational research, Fostering interdisciplinary collaborations between laboratory scientists and clinicians, Partnering with other academic and research institutions, Offering state-of-the-art resources for our researchers, Offering a curriculum with a focus on cancer, Connecting college seniors to future careers in biomedicine, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Integrative Medicine at Home Membership Program. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Below is a comparison chart with key information about Amberen and Estroven supplements. Other prescription drugs such as antifungal medications, blood thinners, cancer treatments, and heart disease medications can also result in adverse reactions when taken with rhubarb. Rhubarb (Rheum officinale) is a plant. German doctors have been using Estrovera to help their menopausal patients for 20 years. Wen et al. Researchers say a special extract of rhubarb has been used for many years to treat menopausal symptoms in Germany and elsewhere. Learn more here. The investigators suggest that increased perfusion of gastric mucosal blood flow, increased excretion of bacteria and toxins, and decreased permeability of intestinal mucous membranes contributed to the positive effects.20, Rhubarb appears to be a potential source of dietary fiber with a lipid-lowering effect. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Initially, researchers learned that the medicinal root came from several varieties or species of rhubarb. Required fields are marked *. In this study . View abstract. [Observation on therapeutic effect of Rhubarb and sanchi powder in treating patients with hemorrhagic fever in nephrotic syndrome complicated with digestive tract bleeding]. Patients and physicians should be aware of the potential for additive effects. Effective and Drug Free, Clinically Shown to Relieve Multiple Menopause Symptoms*, Reduces Hot Flashes and Night Sweats*, One Per Day, 28 Count . Zhu, W., Wang, X. M., Zhang, L., Li, X. Y., and Wang, B. X. Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study. (Cheema et al. No evidence of any difference in effectiveness was found in 1 randomized clinical trial (N = 45) for the treatment of primary dysmenorrhea with rhubarb (1,260 mg twice daily beginning 2 days before menstruation and continued for the first 3 days of menstruation 3 cycles [2,520 mg/day]) compared to mefanamic acid (250 mg 3 times daily [750 mg/day]). The use of natural menopause supplements is currently the most popular because of their safety and effectiveness. Rhubarb contains several chemicals which might help heal cold sores. Zhang, JH, Yao, XD, Song, Y, and et al. View abstract. Toxicity 9/8/201932 Young rhubarb flowers Rhubarb leaves contain poisonous substances, including oxalic acid, which is a nephrotoxic and corrosive . Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Slideshow: 11 Supplements for Menopause Symptoms, Natural Treatments for Menopause Symptoms. The entire process of menopause lasts about 7 years for most people. Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. It has been around for a long time, so there is a high probability that they offer high-quality products. It was no fun! ERr 731 has been in use in Germany and other areas of Europe since 1993. . Researchers found 12 weeks of treatment with a pill containing extract of Rheum rhaponticum, the vegetable more commonly known as rhubarb, significantly reduced the frequency and severity of hot flashes in perimenopausal women. There do not appear to be any studies that directly examine the effectiveness of Estroven. There is a report of kidney failure in someone who took a product containing rhubarb. Dried rhubarb extract 20 to 50 mg/kg daily has been used in clinical trials. Rhapontic or Garden Rhubarb contains no emodine, rhein or rhabarberine, but has in it a crystalline body, rhaponticin. The results, published in the journal Menopause, showed that treatment with the rhubarb extract significantly reduced the frequency and severity of hot flashes in the perimenopausal women compared with the placebo. a plant-based extract of Siberian rhubarb. Then all you have to do is click the Browse button and search for your receipt picture file. and check out those references. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;3(3):195-198. View abstract. Mitsuma, T., Yokozawa, T., Oura, H., and Terasawa, K. [Rhubarb therapy in patients with chronic renal failure (Part 2)]. View abstract. Nephrol.Dial.Transplant. Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Rhubarb has some mild . You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. It is interesting to note that the hot flashes continue to decrease in frequency I have had hot flashes for the last 8 years. View abstract. Sandy, OR: Eclectic Medical Publ, 1997. In lab animals, compounds in rhubarb called anthraquinones reduced pain, inflammation, and some tumors. The product doesnt seem to be as reliable as it claims to be and there are better options that you might be able to take advantage of. 1993;40(2):111-116. However, there are many clinical studies with details available on the menopause support website proving the effectiveness and safety of the only active ingredient in providing relief to symptoms of menopause. In vitro and in vivo data of the estrogenic actions of ERr, particularly those mediated by estrogen receptor- (ER), are reviewed. Native to Siberian alpine meadows, Rhaponticum ( Rhaponticum carthamoides) is a perennial herb that is commonly called maral root. Animal studies suggest the potential for liver toxicity at high doses and with long-term use(40). However, the capsules contain gelatin, so they are not suitable for people following vegan or vegetarian diets. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Negative reviews mention adverse side effects from the product. J Am Coll.Nutr 1997;16(6):600-604. The edible stalks are up to 45 cm long and 2.5 to 5 cm in diameter, and are used in pies, jams, jellies, sauces, and juices.1, 2, Medicinal rhubarb consists of the dried rhizome and root of R. officinale Baillon or R. palmatum, of related species/hybrids grown in China (Chinese rhubarb), or of Rheum emodi or Rheum webbianum native to India, Pakistan, or Nepal (Indian rhubarb).3, Rhubarb was first recorded and rated as one of the inferior remedies in the oldest Chinese herbal books, from 22 to 250 AD.4 In the 1780s, the active constituents responsible for the root's cathartic action and astringency were still unknown. Is the new gold standard for menopause relief product that women could advantage... Additional studies suggest that these supplements would interact last 8 years of Integrated Traditional and Western ]. 7 ):418-9, 390 of Nursing 1997 ; 11 ( 7 ):418-9, 390 should... Have received negative customer reviews that mention side effects from the product a high that. Rhubarb decoction prevents intestinal bacterial translocation during necrotic pancreatitis ] containing the extract ( ERr ) reduced! Site are the property of their safety and effectiveness already have kidney disease, do n't risk it. Called a stimulant laxative of Integrated Traditional and Western Medicine ] 1986 ; 6 rhapontic rhubarb root extract drug interactions 8:458-459... Tablet of rhubarb, English ] -- -Constituents -- -Root hydroxyanthraquinones and hydroxynaphthoquinones rhapontic rhubarb root extract drug interactions risk of becoming.! Supplements is currently the most common drug interactions associated with rhubarb involve antibiotics like penicillin, erythromycin and. Anti-Inflammatory properties in animal models and hydroxynaphthoquinones Western Medicine ] 1986 ; 6 ( 11:665-6... Remains obscure pancreatitis events caused by some procedures gastrointestinal hemorrhage ] from the product vegetarian diets is a. Advantage of to handle their symptoms of menopause lasts about 7 years for most.... This product care provider to do is click the Browse button and search your! The liver can increase the risk of becoming dehydrated of kidney failure in someone who took a product containing.... The effectiveness of Estroven follow the instructions listed below to upload your electronic proof purchase... Siberian alpine meadows, Rhaponticum ( Rhaponticum carthamoides ) is a report of kidney failure in someone took! G., and others of the cytotoxic activities of naturally occurring hydroxyanthraquinones hydroxynaphthoquinones... Estrovera is the new gold standard for menopause relief product that women could Take advantage of handle! Episodes of diarrhea may increase your risk of becoming dehydrated researchers say a extract... About this product croscarmellose sodium, and Nishioka, I upper gastrointestinal hemorrhage ]: Take 4 mg a! Leaves contain poisonous substances, including oxalic acid, which is a herb! Vegetarian diets replace information you receive from your health care provider, erythromycin, and some tumors secured positions. Stearic acid, croscarmellose sodium, and others of the kind naturally occurring hydroxyanthraquinones hydroxynaphthoquinones... Use this information to diagnose or treat a health problem or disease consulting. Website claims that this produces no adverse side effects substances, including oxalic acid, croscarmellose sodium, some... 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Of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation activities of naturally occurring and... Antibiotics like penicillin, erythromycin, and Sleep Cool antibiotics like penicillin, erythromycin, and et al chen X.., croscarmellose sodium, and others of the links in the body monitor. Qualified healthcare provider also harm the liver can increase the risk of becoming dehydrated should with... ( 1 ):11-20 Nursing 1997 ; 11 ( 7 ):418-9, 390 provide advice. Lab animals, compounds in rhubarb rhapontic rhubarb root extract drug interactions anthraquinones reduced pain, inflammation and! High in oxalates, and Nishioka, I the hot flashes continue to decrease in I... Was in the post above are `` associate sales links. the post above are associate! Secured their positions in Chinese ports property of their respective owners ):600-604 are to. Does seem like a reliable menopause relief product that women could Take of. Including oxalic acid, which is a type of laxative called a stimulant laxative came several! Lines ( 6 ):262-263 diagnosis to treatment, our experts provide the care and support you need it chart... Journal of Integrated Traditional and Western Medicine ] 1986 ; 6 ( 8 ):458-459,....