I dont know. Now we are waiting for the verdict: whether its an infection in his bladder or stones. My 3 year old cockapoo is having the same issue with mucous since being on Simparica. I will never give my dog this medication again. She is shaking and panting heavy. They keep telling me that she would have been sick from the first pill, not just the 2nd. Then she lost control of her legs and couldn't walk or stand. I rescued a dog that had a light case of heartworms. I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. Thannks !! In January, he was boarded and the boarder asked us if he could possibly be blind. this link is to an external site that may or may not meet accessibility guidelines. Clinical Pharmacology 2-6 days in vomiting here and there. We were not sure it was simparica. Thank you all so much!!!! She was ok for awhile, then she had a seizure and started throwing up all over the house. My 5 year old, healthy Australian Shepherd had a check-up + boosters at the vet on January 24th. Here is the safety info from the manufacturer Zoetis: SIMPARICA TRIO was administered orally to 8weekold Beagle puppies at doses of 1, 3, and 5X the maximum labeled dose (2.4 mg/kg sarolaner, 48 g/kg moxidectin, and 10 mg/kg pyrantel) at 28 day intervals for 7 treatments. A couple of weeks later she had lost weight from not eating. thank you. My dog was super sick the first months of his life. The Maltese mix is lethargic and wont jump on bed or couch. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. Within 24 hours, he would not leave my bedroom, slept all day, no appetite. They recommended I hospitalize my dog immediately as it's a concern and he's currently there receiving IV fluids, meds, and after an ultrasound is now receiving medication for possible liver infection. The other has had diarrhea every since 6 hours after the pill. Took him to the vet Potassium level was so high they did an ekg and his heart was not beating regular. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Was hospitalized for 2 1/2 days. I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. He is acting very skittish/scared like behavior, wants to just lay down. My sincere sympathies to those with horrendous seizure side effects. My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. The reason I had stopped it , I saw a Instagram where a girls dog took the. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. 24 hours later she had another one. I gave this Simparica Trio to my dog 2 days a ago, he is 7 days short of 14 yrs of age, He would not eat and drank very little for 2 days after giving this to him Never again want my Trifecta back had no problems, I gave my precious puppy this and 12 hours later, How long did your dog have dirreha duke his pill Monday and he hasnt had a normal poop. Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. Could this be caused by the med? Im beyond heartbroken, shocked, and sad. I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. I took him to the ER they checked his vitals and sent me home. This is lethal medication for dogs and should be taken off the market now. Is it just me or does it seem like everyone is in this together? Not Trio because of all the seizure horror stories. We rushed to the vets who said it had to be neurological and once I mentioned the diarrhea she looked into Simparica suspecting MDR1 with my dog. I am currently in the same situation and we are at day 16 after giving simparica. My dog weighs 60 pounds and was given a dose for dogs up to 88 pounds. I will not be giving this medication again! She also started with ear infections. I will never give him this drug again. Does any one think this could be a reaction to Simparico Trio? Now her dog is very sick and she has to take the dog to the vet every day in the past week. How can they put something that can cause this level of damage on the market and how do vets not even tell us to monitor our pets or tell us what the risks are. My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. The vet suggested Simparico trio . Im trying to understand how. He had an MRI and it came out good. For 5 years I have resisted my veterinarians suggestions for oral flea meds. Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. Product (Reports), Deaths/%, Seizures/% Nexgard 18. I give my dogs Simparica at the beginning of each month. I am so mad at myself and so upset that I am the one that has made him sick. In the meantime i keep trying to give him ice and i am very worried that i have permanently harmed him. Also vets needs to tell the truth!!! When he lays in the sun you can see the bumps under his skin. And urinating more often as a result. Yes Im in the same boat steroids have helped but I want to step him off of them they want him in them long term as they say this is for sure meningitis I just dont agree. Seizure meds arent working. Reading your comments, this drug may be the cause. It is really eye-opening to see everyone's experiences. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. I am hoping it is almost all out of her system. She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. MONEY!!. Omg, this is beyond awful and makes me so worried. I am extremely upset at myself for letting a similar but very serious threat get to my pup again. I know it's still in her system because I am still finding dead ticks that I miss because they are the size of a sesame seed. However, the following side effects are seen in less than 1 dog in 10,000: mild and short-lived vomiting and diarrhoea as well as tremor (shaking), ataxia (inability to coordinate body movements) or convulsions. Today shes been panting. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. Omg my girl goes threw incredible itching this has lead to us takeing her to the vet because she gets infected from scratching herself to death. We had family in for the weekend and he was not himself. He has become more aggressive and has been growling at me sometimes when I try to move him. Our two shih tzus are 6.5. Some dogs also experience a temporary loss of appetite and may not eat their food at their usual meal times. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . . It is recommended to wash your hands after administering this medication. Im so upset with myself. There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. My vet recommended the tablet to save on monthly costs for flea and tick treatment. Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! When we took him to the emergency vet they waved us off when we brought in the package, inquiring if it was the cause. I'll be calling them tomorrow. Just gave my baby her first dose. It's been a little over two months since her last dose and feel certain that is what almost killed her. Insurance for dogs, cats, and other household animals can run as low as $20 a month, but that cost can add up over time. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. The only thing we changed after his checkup if Feb. was his flea and tick treatment. Chewable tablets can be given directly to your dog or broken up and mixed with food. Why the vets use this treatment after so many side effects being reported is disgusting. There is also a chance that hell need a surgery. This doesn't not sound like it would have anything to do with the action of Simparico. This past October he just wasn't the same. After reading all these reports I am convinced this is the reason our baby is so sick. I am giving her supplements to support her heart and nerves and she's a little better each day. High on the list was Simparica Trio. Our 9 month 5lb Morkie was prescribed this garbage and we noticed the shakes, his lower lip quivering, and he looks around as if an invisible fly is flying around his head. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. The company is reimbursing for vet costs. No appetite, not like Charlie. But anyways - the other night , his feet collapsed from under him & he fainted . Some had fleas, some had heartworms, and some had roundworms. He was lethargic & laying in his crate alot . Our 3 mo.old Boston Terrier, 10 lbs, had her first dose of Simparaco yesterday. I just gave Bentlee my Akita Simparica Trio on the 9th. The vet has reported it (at least she too thinks it came from the drug) and a chiropractor checked her for the possiblility of slipped disc etc and said it's not that. 10 days after taking Simparica, she started having muscle tremors. Instead, it kills larvae, allowing your dog to avoid infection. So we went home with her on steroids and more antibiotics and denamrin for liver. Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. We did get a little symptom improvement from prednisone if they are having other neurological issues. I cant believe how long this thread is. Best of luck. They kindly asked that we schedule an immediate check and diagnostic testing at our local vet. The diarrhea also went away yesterday evening. Two days later, she is doing better, but not 100% yet. Same as you describe. 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