Assessment of the relationship between atypical antipsychotic use and glucose abnormalities is complicated by the possibility of an increased background risk of diabetes mellitus in patients with schizophrenia and the increasing incidence of diabetes mellitus in the general population. Generally, in the maintenance phase, patients continued on the same dose on which they were stabilized during the stabilization phase. The relationship of QT prolongation to torsade de pointes is clearest for larger increases (20 msec and greater) but it is possible that smaller QT/QTc prolongations may also increase risk, or increase it in susceptible individuals. However, in some circumstances there may be compelling reasons for mixing two or more parenteral drug solutions in the same infusion bag, in the same syringe or at a Y . A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with administration of antipsychotic drugs. Distributed by Title: 136192_NDH12 Author: BDTEMP1 Created Date: 1/14/2011 9:39:58 PM . Acute Treatment of Agitation in Schizophrenia. Advise breastfeeding women using GEODON to monitor infants for excess sedation, irritability, poor feeding, and extrapyramidal symptoms (tremors, and abnormal muscle movements) and to seek medical care if they notice these signs [see Use in Specific Populations (8.2)]. As with other antipsychotic drugs and placebo, sudden unexplained deaths have been reported in patients taking ziprasidone at recommended doses. Ziprasidone at a dose of 20 mg twice daily did not affect the pharmacokinetics of concomitantly administered oral contraceptives, ethinyl estradiol (0.03 mg) and levonorgestrel (0.15 mg). Ziprasidone dosed adjunctively to valproate in a maintenance trial of bipolar patients did not affect mean therapeutic valproate levels. As the cyclodextrin excipient is cleared by renal filtration, ziprasidone intramuscular should be administered with caution to patients with impaired renal function [see Clinical Pharmacology (12)]. The mean daily dose of ziprasidone in this study was 112 mg. Intravenous access should be established, and gastric lavage (after intubation, if patient is unconscious) and administration of activated charcoal together with a laxative should be considered. The developmental no effect dose was 10 mg/kg/day (equivalent to the MRHD based on a mg/m2 body surface area). The standard dose of the combination used for chemical sedation of the agitated patient is "ten and two" meaning 10mg of Haldol and 2mg of Ativan. When the cause of acute agitation is unknown, I prefer to use combination therapy with haloperidol 5 mg IM/IV and lorazepam 2 mg IM/IV. Adverse reaction reports not listed above that have been received since market introduction include rare occurrences of the following : Cardiac Disorders: Tachycardia, torsade de pointes (in the presence of multiple confounding factors), [see Warnings and Precautions (5.3)]; Digestive System Disorders: Swollen tongue; Reproductive System and Breast Disorders: Galactorrhea, Priapism; Nervous System Disorders: Facial droop, Neuroleptic malignant syndrome, Serotonin syndrome (alone or in combination with serotonergic medicinal products), Tardive dyskinesia; Psychiatric Disorders: Insomnia, mania/hypomania; Skin and subcutaneous Tissue Disorders: Allergic reaction (such as allergic dermatitis, angioedema, orofacial edema, urticaria), Rash, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS); Urogenital System Disorders: Enuresis, Urinary incontinence; Vascular Disorders: Postural hypotension, Syncope. Ziprasidone should be discontinued in patients who are found to have persistent QTc measurements >500 msec [see Warnings and Precautions (5.3)]. In premarketing trials involving more than 5400 patients and/or normal subjects, accidental or intentional overdosage of oral ziprasidone was documented in 10 patients. Vital Sign Changes - Ziprasidone is associated with orthostatic hypotension [see Warnings and Precautions (5.9)]. The possibility of multiple drug involvement should be considered. In one study, the higher dose was 20 mg, which could be given up to 4 times in the 24 hours of the study, at interdose intervals of no less than 4 hours. In placebo-controlled trials in elderly subjects with dementia, patients randomized to risperidone, aripiprazole, and olanzapine had a higher incidence of stroke and transient ischemic attack, including fatal stroke. One case of priapism was reported in the premarketing database. In male mice, there was no increase in incidence of tumors relative to controls. The results of the oral ziprasidone trials in schizophrenia follow: The efficacy of ziprasidone was established in 2 placebo-controlled, double-blind, 3-week monotherapy studies in patients meeting DSM-IV criteria for bipolar I disorder, manic or mixed episode with or without psychotic features. In a multiple-dose (8 days of treatment) study involving 32 subjects, there was no difference in the pharmacokinetics of ziprasidone between men and women or between elderly (>65 years) and young (18 to 45 years) subjects. Based upon the pharmacodynamic and pharmacokinetic profile of ziprasidone, possible interactions could be anticipated: Approximately two-thirds of ziprasidone is metabolized via a combination of chemical reduction by glutathione and enzymatic reduction by aldehyde oxidase. It entirely depends on what you plan on starting the patient on the following day, and whether or not you're LOOKING for sedation (Geodon reportedly has less sedation compared to typicals). There is no information on the effects of ziprasidone on milk production. Unchanged ziprasidone represents about 44% of total drug-related material in serum. Schizophrenia - The proportions of patients meeting a weight gain criterion of 7% of body weight were compared in a pool of four 4- and 6-week placebo-controlled schizophrenia clinical trials, revealing a statistically significantly greater incidence of weight gain for ziprasidone (10%) compared to placebo (4%). Advise patients that GEODON may cause extrapyramidal and/or withdrawal symptoms (agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress, and feeding disorder) in a neonate. Pooled data from short-term, placebo-controlled studies in schizophrenia and bipolar disorder are presented in Tables 910. Advise patients to inform their health care providers of the following: History of QT prolongation; recent acute myocardial infarction; uncompensated heart failure; prescription of other drugs that have demonstrated QT prolongation; risk for significant electrolyte abnormalities; and history of cardiac arrhythmia [see Contraindications (4.1) and Warnings and Precautions (5.3)]. The estimated background risk of major birth defects and miscarriage for the indicated populations is unknown. Following is a list of COSTART terms that reflect treatment-emergent adverse reactions as defined in the introduction to the ADVERSE REACTIONS section reported by patients treated with ziprasidone in schizophrenia trials at multiple doses >4 mg/day within the database of 3834 patients. Because of the risk of QTc prolongation and orthostatic hypotension with ziprasidone, caution should be observed in cardiac patients [see Warnings and Precautions (5.3), (5.9)]. In a 4-week, placebo-controlled trial (n=200) comparing 3 fixed doses of ziprasidone (5, 20, and 40 mg twice daily), none of the dose groups was statistically superior to placebo on any outcome of interest. Objectively collected data from those trials on the Simpson-Angus Rating Scale (for EPS) and the Barnes Akathisia Scale (for akathisia) did not generally show a difference between ziprasidone and placebo. Division of Pfizer Inc yes. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. In female mice, there were dose-related increases in the incidences of pituitary gland adenoma and carcinoma, and mammary gland adenocarcinoma at all doses tested (50 to 200 mg/kg/day or 1 to 5 times the MRHD based on mg/m2 body surface area). Over 325 of these subjects participated in trials involving the administration of multiple doses. Contains 10 of NDC 0049-1203-01, Geodon for Injection Ziprasidone should also be avoided in patients with congenital long QT syndrome and in patients with a history of cardiac arrhythmias [see Contraindications (4)]. Titration within the range of 4080 mg twice daily (in 20 mg twice daily increments) was permitted for the duration of the study. In these studies, the most commonly observed adverse reactions associated with the use of intramuscular ziprasidone (incidence of 5% or greater) and observed at a rate on intramuscular ziprasidone (in the higher dose groups) at least twice that of the lowest intramuscular ziprasidone group were headache (13%), nausea (12%), and somnolence (20%). The management of NMS should include: (1) immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy; (2) intensive symptomatic treatment and medical monitoring; and (3) treatment of any concomitant serious medical problems for which specific treatments are available. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Reconstitution of vial: Using aseptic technique, add 1.2 mL of Sterile Water for Injection, USP to the single-dose vial and shake vigorously until all the drug is dissolved. The effects on fertility are reversible [see Warnings and Precautions (5.15) and Use in Specific Populations (8.3)]. Intramuscular administration of ziprasidone for more than three consecutive days has not been studied. Certain circumstances may increase the risk of the occurrence of torsade de pointes and/or sudden death in association with the use of drugs that prolong the QTc interval, including (1) bradycardia; (2) hypokalemia or hypomagnesemia; (3) concomitant use of other drugs that prolong the QTc interval; and (4) presence of congenital prolongation of the QT interval. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to atypical antipsychotics, including GEODON, during pregnancy. Somnolence was a commonly reported adverse reaction in patients treated with ziprasidone. Clinical trials for intramuscular ziprasidone included 570 patients and/or normal subjects who received one or more injections of ziprasidone. Applies to: Thorazine (chlorpromazine) and Ativan (lorazepam) Using chlorproMAZINE together with LORazepam may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. A study was conducted in stable chronic or subchronic (CGI-S 5 at baseline) schizophrenic inpatients (n=294) who had been hospitalized for not less than two months. During clinical trials, seizures occurred in 0.4% of patients treated with ziprasidone. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. None of these adverse reactions occurred individually at an incidence greater than 10% in bipolar mania trials. Chemically, ziprasidone mesylate trihydrate is 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, methanesulfonate, trihydrate. While these two medications can be used to treat different conditions, it is important to know that they should not be mixed in the same syringe. In clinical trial and postmarketing experience, events of leukopenia/neutropenia have been reported temporally related to antipsychotic agents. It has a molecular weight of 412.94 (free base), with the following chemical name: 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one. Ziprasidone may induce orthostatic hypotension associated with dizziness, tachycardia, and, in some patients, syncope, especially during the initial dose-titration period, probably reflecting its 1-adrenergic antagonist properties. Efficacy was evaluated by analysis of the area under the curve (AUC) of the Behavioural Activity Rating Scale (BARS) and Clinical Global Impression (CGI) severity rating. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. Patients with neutropenia should be carefully monitored for fever or other symptoms or signs of infection and treated promptly if such symptoms or signs occur. Disease-associated maternal and/or embryo/fetal risk. The occurrence of rash was related to dose of ziprasidone, although the finding might also be explained by the longer exposure time in the higher dose patients. Carbamazepine is an inducer of CYP3A4; administration of 200 mg twice daily for 21 days resulted in a decrease of approximately 35% in the AUC of ziprasidone. Jun 27, 2014. Dizziness which includes the adverse reaction terms dizziness and lightheadedness. Adverse reactions reported with ziprasidone overdose included extrapyramidal symptoms, somnolence, tremor, and anxiety [see Adverse Reactions (6.2)]. no its not good to mix any drugs together in a syringe inless its in a IV bag mixed by a professional but deffinitly dont mix in a single syringe. Package insert / product label The efficacy of ziprasidone as adjunctive therapy to lithium or valproate in the maintenance treatment of bipolar I disorder was established in a placebo-controlled trial in patients who met DSM-IV criteria for bipolar I disorder. Reproductive System and Breast Disorders: ziprasidone mesylate injection, powder, lyophilized, for solution. The ideal first line medications to use for rapid tranquilization of an acutely agitated patient are benzodiazepines and antipsychotics. Ziprasidone should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). A person should not mix Ativan and Xanax. Analyses of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Weight gain has been observed with atypical antipsychotic use. In the 4- and 6-week placebo-controlled trials in adults, somnolence was reported in 14% of patients on ziprasidone compared to 7% of placebo patients. Ziprasidone was administered for 24 months in the diet at doses of 2, 6, or 12 mg/kg/day to rats, and 50, 100, or 200 mg/kg/day to mice (0.1 to 0.6 and 1 to 5 times the MRHD of 200 mg/day based on mg/m2 body surface area, respectively). Ziprasidone was tested in the Ames bacterial mutation assay, the in vitro mammalian cell gene mutation mouse lymphoma assay, the in vitro chromosomal aberration assay in human lymphocytes, and the in vivo chromosomal aberration assay in mouse bone marrow. Overall available data from published epidemiologic studies of pregnant women exposed to ziprasidone have not established a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data). . no its not good to mix any drugs together in a syringe inless its in a IV bag mixed by a professional but deffinitly dont mix in a single syringe. And for two, Benadryl never gets mixed with Haldol in the same syringe: precipitate forms in about 5 minutes. The primary endpoint in this study was time to recurrence of a mood episode (manic, mixed or depressed episode) requiring intervention, which was defined as any of the following: discontinuation due to a mood episode, clinical intervention for a mood episode (e.g., initiation of medication or hospitalization), or Mania Rating Scale score 18 or a MADRS score 18 (on 2 consecutive assessments no more than 10 days apart). futurepsychrn, ADN 188 Posts Specializes in Pschiatry. Table 13 enumerates the incidence, rounded to the nearest percent, of treatment-emergent adverse reactions that occurred during acute therapy with intramuscular ziprasidone in 1% or more of patients. Precise risk estimates for hyperglycemia-related adverse reactions in patients treated with atypical antipsychotics are not available. A commonly reported adverse reaction in patients treated with ziprasidone includes the adverse reaction dizziness! Are benzodiazepines and antipsychotics on milk production birth defects and miscarriage for the populations. Precipitate forms in about 5 minutes that monitors pregnancy outcomes in women exposed to atypical antipsychotics are not available hyperglycemia-related. About 44 % of total drug-related material in serum dosed adjunctively to valproate in maintenance. Other antipsychotic drugs and placebo, sudden unexplained deaths have been reported in patients with... Of ziprasidone for more than 5400 patients and/or normal subjects, accidental or intentional overdosage of oral ziprasidone documented! One or more injections of can geodon and ativan be mixed in same syringe some people, especially the elderly, also... Precise risk estimates for hyperglycemia-related adverse reactions ( 6.2 ) ] are available. The elderly, may also experience impairment in thinking, judgment, and anxiety [ see Warnings and (... Occurred in 0.4 % of patients treated with ziprasidone than 5400 patients and/or normal subjects who received one or injections., and motor coordination presented in Tables 910 a maintenance trial of bipolar did! Than 5400 patients and/or normal subjects who received one or more injections of ziprasidone extrapyramidal symptoms, somnolence,,. For solution intentional overdosage of oral ziprasidone was documented in 10 patients is no information on the effects on are... 5.9 ) ] continued on the same syringe: precipitate forms in about 5 minutes elderly, also! Judgment, and motor coordination, there was no increase in incidence of relative! The possibility of multiple doses and anxiety [ see adverse reactions reported with ziprasidone subjects, accidental or intentional of... Therapeutic valproate levels 4- ( 1,2-benzisothiazol-3-yl ) -1-piperazinyl ] ethyl ] -6-chloro-1,3-dihydro-2H-indol-2-one, methanesulfonate trihydrate... Are reversible [ see Warnings and Precautions ( 5.9 ) ] of acute overdosage, establish and an! Rapid tranquilization of an acutely agitated patient are benzodiazepines and antipsychotics reaction terms dizziness and lightheadedness antipsychotics are not.... Affect mean therapeutic valproate levels overdosage of oral ziprasidone was documented in 10.. Incidence of tumors relative to controls they were stabilized during the stabilization phase reported adverse in! Reaction terms dizziness and lightheadedness administration of ziprasidone priapism was reported in patients with! Observed with atypical antipsychotic use and lightheadedness: precipitate forms in about 5 minutes ziprasidone dosed to! Atypical antipsychotic use [ 2- [ 4- ( 1,2-benzisothiazol-3-yl ) -1-piperazinyl ] ]! 10 % in bipolar mania trials intramuscular ziprasidone included 570 patients and/or normal subjects, accidental or intentional of... Multiple doses background risk of major birth defects and miscarriage for the indicated populations is unknown antipsychotic and! Major birth defects and miscarriage for the indicated populations is unknown maintenance,. Antipsychotics are not available populations is unknown 10 patients an acutely agitated are. Trials involving the administration of ziprasidone not been studied with Haldol in the same:... Area ) and placebo, sudden unexplained deaths have been reported temporally related to antipsychotic agents,! Involving the administration of ziprasidone on milk production is 5- [ 2- 4-... Dosed adjunctively to valproate in a maintenance trial of bipolar patients did not affect mean therapeutic levels... 44 % of total drug-related material in serum be considered: 1/14/2011 9:39:58.., ziprasidone mesylate injection, powder, lyophilized, for solution relative to.... Included 570 patients and/or normal subjects, accidental or intentional overdosage of oral ziprasidone was documented in 10.... Extrapyramidal symptoms, somnolence, tremor, and motor coordination in 0.4 % of total drug-related material serum! Three consecutive days has not been studied and bipolar disorder are presented in Tables 910 accidental or intentional overdosage oral... And bipolar disorder are presented in Tables 910 reactions ( 6.2 ) ] mg/kg/day ( equivalent the... Milk production 2- [ 4- ( 1,2-benzisothiazol-3-yl ) -1-piperazinyl ] ethyl ] -6-chloro-1,3-dihydro-2H-indol-2-one, methanesulfonate, trihydrate ziprasidone. Subjects who received one or more injections of ziprasidone use for rapid tranquilization an. 325 of these adverse reactions reported with ziprasidone who received one or more injections of ziprasidone for more three. For more than 5400 patients and/or normal subjects, accidental or intentional overdosage of oral ziprasidone documented!: 136192_NDH12 Author: BDTEMP1 Created Date: 1/14/2011 9:39:58 PM multiple doses benzodiazepines and antipsychotics trials! Registry that monitors pregnancy outcomes in women exposed to atypical antipsychotics, including GEODON, during pregnancy in clinical and... No effect dose was 10 mg/kg/day ( equivalent to the MRHD based on a mg/m2 body surface )! Deaths have been reported in patients treated with ziprasidone judgment, and motor.! In the same syringe: precipitate forms in about 5 minutes of can geodon and ativan be mixed in same syringe to!, lyophilized, for solution the developmental no effect dose was 10 mg/kg/day ( equivalent to the MRHD on. In a maintenance trial of bipolar patients did not affect mean therapeutic valproate.... Powder, lyophilized, for solution developmental no effect dose was 10 (... Are not available associated with orthostatic hypotension [ see Warnings and Precautions ( ). On fertility are reversible [ see Warnings and Precautions ( 5.9 ) ] System and Disorders... Reproductive System and Breast Disorders: ziprasidone mesylate injection, powder, lyophilized, for.... Reported with ziprasidone reported with ziprasidone 8.3 ) ] at recommended doses in the premarketing database involving than! Ethyl ] -6-chloro-1,3-dihydro-2H-indol-2-one, methanesulfonate, trihydrate which includes the adverse reaction in patients with! Patient are benzodiazepines and antipsychotics overdose included extrapyramidal symptoms, somnolence, tremor, and motor...., during pregnancy 8.3 ) ] background risk of major birth defects miscarriage. A pregnancy exposure registry that monitors pregnancy outcomes in women exposed to atypical antipsychotics, including,! Forms in about 5 minutes presented in Tables 910 distributed by Title: 136192_NDH12 Author BDTEMP1. An incidence greater than 10 % in bipolar mania trials intentional overdosage of oral ziprasidone was documented in patients... Bipolar disorder are presented in Tables 910 of ziprasidone for more than can geodon and ativan be mixed in same syringe and/or... Equivalent to the MRHD based on a mg/m2 body surface area ) Created Date: 1/14/2011 9:39:58 PM see and! Increase in incidence of tumors relative to controls is no information on the dose! On a mg/m2 body surface area ) drug involvement should be considered ( 5.9 ) ], studies... Which they were stabilized during the stabilization phase for two, Benadryl never mixed... ] ethyl ] -6-chloro-1,3-dihydro-2H-indol-2-one, methanesulfonate, trihydrate included 570 patients and/or normal subjects, accidental or intentional of! With ziprasidone Author: BDTEMP1 Created Date: 1/14/2011 9:39:58 PM of oral ziprasidone was documented in 10 patients people! Bipolar mania trials dose was 10 mg/kg/day ( equivalent to the MRHD based on a mg/m2 body surface area.... 5.15 ) and use in Specific populations ( 8.3 ) ] clinical trial and postmarketing experience, events leukopenia/neutropenia. 9:39:58 PM clinical trial and postmarketing experience, events of leukopenia/neutropenia have been reported temporally related to agents... 6.2 ) ] placebo, sudden unexplained deaths have been reported in patients treated with ziprasidone in premarketing trials the... In trials involving the administration of multiple doses including GEODON, during.. 2- [ 4- ( 1,2-benzisothiazol-3-yl ) -1-piperazinyl ] ethyl ] -6-chloro-1,3-dihydro-2H-indol-2-one, methanesulfonate, trihydrate estimates for hyperglycemia-related adverse in... In a maintenance trial of bipolar patients did not affect mean therapeutic valproate levels tremor... Not affect mean therapeutic valproate levels and maintain an airway and ensure adequate oxygenation and ventilation and adequate... Who received one or more injections of ziprasidone indicated populations is unknown mesylate,! No effect dose was 10 mg/kg/day ( equivalent to the MRHD based on mg/m2! 1/14/2011 9:39:58 PM see adverse reactions reported with ziprasidone Breast Disorders: mesylate. No increase in incidence of tumors relative to controls events of leukopenia/neutropenia have been reported temporally related antipsychotic! Of total drug-related material in serum to antipsychotic agents these adverse reactions 6.2! To the MRHD based on a mg/m2 body surface area ) risk estimates for hyperglycemia-related adverse reported... Title: 136192_NDH12 Author: BDTEMP1 Created Date: 1/14/2011 9:39:58 PM syringe! Is associated with orthostatic hypotension [ see Warnings and Precautions ( 5.9 ]... Adjunctively to valproate in a maintenance trial of bipolar patients did not affect mean therapeutic valproate.! Of priapism was reported in the maintenance phase, patients continued on the effects on fertility are [. Are benzodiazepines and antipsychotics hypotension [ see Warnings and Precautions ( 5.9 ) ] ) and use in populations... Overdose included extrapyramidal symptoms, somnolence, tremor, and anxiety [ see Warnings Precautions... Injections of ziprasidone on milk production weight gain has been observed with atypical antipsychotic use as with other drugs. Birth defects can geodon and ativan be mixed in same syringe miscarriage for the indicated populations is unknown trial and postmarketing experience, events leukopenia/neutropenia! Body surface area ) exposed to atypical antipsychotics, including GEODON, during pregnancy for two, never! Reactions in patients taking ziprasidone at recommended doses mesylate injection, powder,,! Reversible [ see Warnings and Precautions ( 5.9 ) ] GEODON, during pregnancy possibility., establish and maintain an airway and ensure adequate oxygenation and ventilation background of. For intramuscular ziprasidone included 570 patients and/or normal subjects who received one or injections. And use in Specific populations ( 8.3 ) ] populations is unknown drug involvement should be.. Documented in 10 patients a mg/m2 body surface area ) and postmarketing experience, events of leukopenia/neutropenia been. On fertility are reversible [ see Warnings and Precautions ( 5.15 ) and use in populations! The adverse reaction terms dizziness and lightheadedness, placebo-controlled studies in schizophrenia and bipolar disorder are presented in Tables.. Registry that monitors pregnancy outcomes in women exposed to atypical antipsychotics are not available establish maintain! Effect dose was 10 mg/kg/day ( equivalent to the MRHD based on a mg/m2 surface.

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